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POLYPURE SECURES MAJOR PEG SUPPLY CONTRACT WITH BD BIOSCIENCES FOR EXPANDING MOLECULAR DIAGNOSTIC RANGE Highly purified monodisperse PEGS boost binding and affinity Oslo, Norway, October 20, 2008 – Scandinavian-based PEG specialist Polypure today announced that it has signed a five-year contract to supply BD Biosciences, a segment of BD, with specialist PEGs for its existing and in-development diagnostic ranges. BD is the latest major medical technology company to recognise the advantages of Polypure's monodisperse products, which offers significant performance and cost advantages over polydisperse PEG derivatives. Polypure Marketing Director Magali Le Bomin lists these benefits as: "The polymer homogeneity achieved by using our patented Sample Displacement Chromatographic purification method ensures a high level of functional integrity. Likewise, the single molecular weight avoids the characterisation problems of usual polymer mixtures. In diagnostics we can significantly improve cross-linking, binding and lot-to-lots reproducibility. Furthermore, there is the overriding benefit of being able to reduce diagnostic complexity which has a significant impact on development, regulatory and production times." Marybeth Sharkey of BD Biosciences commented that Polypure PEGs met the exacting design specifications and quality demands set by their R&D division. "Since working with Polypure, we have noted a marked quality improvement and consistency due to the quality of Polypure's PEG compounds." POLYPURE INTRODUCES KEY MONODISPERSED PEG COMPOUND Maleimidopropionyl-PEG significantly enhances assay and drug optimisation Oslo, Norway, October 17, 2007 – Following successful customer trials, the Scandinavian-based PEG specialist Polypure has launched its latest monodispersed PEG derivative – Maleimidopropionyl-PEG NHS ester. This heterobifunctional PEG is designed to improve crosslinking between compounds carrying amino groups and thiol functions and is attracting widespread interest from both diagnostic and pharmaceutical developers.
According to Polypure Marketing Director Magali Le Bomin, this new PEG fully demonstrates the increasingly acknowledged benefits of monodispersed PEGs: “The polymer homogeneity achieved by using our patented Sample Displacement Chromatographic purification method ensures a high level of functional integrity. Likewise, the single molecular weight avoids the characterisation problems of polydispersed polymer mixtures. Looking at applications, for diagnostics we can significantly improve cross-linking, binding and lots reproducibility. Similarly for pharmaceuticals, the extended PEG space length enhances the solubility of poorly soluble drugs. Furthermore, there is the overriding benefit of being able to reduce diagnostic and drug design complexity which has a significant impact on development, regulatory and production times.”
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